Do not hesitate to leave a regional to go to a major, especially NOW when regionals are curtailing their operations. Better to be at NK or F9 flying your@$$ off as an FO than on reserve barely flying because the company no longer has enough CAs to keep their operations going enough to get the FOs the 1000 hrs they need to upgrade.

The landscape is becoming littered with the carcasses of dead and dying regionals and an A320 type and hours makes you a lot more attractive should you want to move on to a legacy than a CRJ type does.