Like everything else in life there are pros and cons. If you want to make as much money as possible, 121 is the way to go. If you're tired of the commute and have no intention of moving to a major hub, flying for a frac would eliminate that problem. The health insurance at NetJets is arguably the best you'll find in the industry, including the big 3 legacies. Premiums 100% covered and zero deductible.
I've done both and decided to commit to the fractional side. No more 3 hour sit in a 737 jumseat to EWR the night before my trip, and the flying is just more interesting.
That's my take. To each their own.