CVG = Mostly domestic Amazon. A couple domestic DHL routes. International will be DHL to Europe, has been LEJ or EMA this year. Some Inter-Asia laps out of ICN.

JFK = Mostly charter pax. Both domestic and International. Some domestic lines flying Amazon or DHL.

Big difference is the first and last day of the pattern. CVG is likely always an operating leg, where JFK is likely always a commercial DH from JFK... meaning alternate travel on day 1 from home to the jet vice gateway travel on day 0 to base.

Spend week or two on FlightRadar24 creeping on GTI and PAC flights and also look at what the jet has done the past week, and you will get the jist.