Friday to Monday, Friday to Sunday, or Saturday to Monday is possible. I did it in the RJ days, because it was the only days you had a prayer of getting a livable, commutable schedule. Saturday Sunday exclusively is not that realistic because you may not reach the required credit value to make a schedule unless you do some, and the airline allows, dropping to keep your flying on those days and that’s if they have the reserves to allow that which in this day and age, especially on the peak months…good luck.