If you're looking for variety in destinations, assuming you're still young, maybe as soon as you think you have logged "enough" Part 121 hours (whatever that means for you), go try the fractional/corporate lifestyle (if you haven't already) while waiting for a call from a major. Never know, you might find that it's a good long-term fit for you. I personally don't think the majors hiring is gonna stop anytime soon, but I thought the same thing during the summer of 2001... just never know. if it does stop, where would you rather be for another 4-5 years before it starts back up again: continuing the regional slog? or serving catering and cleaning your own bizjet (until your SIC is doing that for you) while flying into a neat new destination on occasion?

might not be the best "book" answer, but sometimes life isn't about following the best "book" answers... it's personal.