I gaurantee your wife is not going to want to slog into the city 2 or 3 days a week from santa rosa to oracle park. its not in an easy location to get to, as you either have to go across the bay bridge or go thru downtown at rushhour both ways. (unless she can work 5am-1pm) Once you go north of novato there is lot more traffic, although they are adding a lane to the freeway, not sure if its done yet. should help a bit.
with no kids i would suggest renting in the city for a year and see how you like it. There are a lot of rentals right by the park, not sure of the rents over there. the park to the airport is about 20 minutes depending on traffic.