Sleep cycle is a pretty big deal though, at least for me personally. Nothing will nuke your test levels faster than working the back side of the clock. Also it ages the crap out of you and brings about other health issues as you get older.

I suppose there's always TRT, but now that the FAA started recently cracking down on it I wouldn't be so quick to roll the dice with my medical. Hard pass.

I've done a lot of flying through the WOCL, and I feel like a completely different person when I'm sleeping at night and not fighting mother nature. YMMV on that though.