I'm flying for a regional and finishing my degree online, and it's not that bad. I'm sitting reserve, and my company's pretty fat on FOs, so I have plenty of time to sit on my laptop and watch lectures and answer questions, etc. Factors that can make a big difference are, which degree you're pursuing, how much of your degree you have finished, and which classes your school offers online. It's a good idea to have your AA and any prerequisites for your degree finished before you start a flying job. I'm working towards an Engineering Technology degree and finding out the hard way that while all of the upper level courses are offered online, some of the lower level prerequisites, that are not part on an AA are not available online.