I personally wouldn't care to drive 4 hours for every trip. You have to consider how alert you will be for a full duty day if you leave the house possibly 5 1/2 to 6 hours before pushback. I suppose you could leave a little earlier and catch a nap before show time, which means you would leave maybe 7 to 8 hours before pushback? You might do better just driving to the nearest airport and flying, whether it's SDF or MIA. There are number of folks that drive similar distances and they manage it, so it would just depend on your pain tolerance.