I guess I'll add my experience, too. I flew passenger charter for ACMI carrier before Delta. I miss (In no particular order): Home basing, International business class travel (and all the perks that come with it), being off half the month in one big block, seeing the world and never knowing where I was going to go when I went to work. At times it was like being a mercenary pilot and it was quite an adventure. With that all in mind...

Money: This is better. Retirement contributions are such a huge part of the picture, and even base reserve pay here is 12-15 more hours a month of credit. Not to mention profit sharing.
Time: This is a wash probably. I have to manage my time at home more carefully now and I don't get to do as much personal travel or fun stuff as I used to. That will improve as time goes on.
Stability: I once flew with a guy who was on his 21st 121 carrier. The road is littered with the carcasses of dead ACMI operators, even some big ones. I believe that Delta is my final career stop. I was never *really* certain of that at the other place.
Health: This is better for my body. Hitting three or four (or more) theaters in one rotation, and in random order, is taxing. The older I get the more I like being within 2 time zones of home.

My ACMI, for all of its faults, was the girlfriend that was just too crazy to marry but had a great personality and was a helluva lot of fun. But you just never knew when she was going to key your car. I miss that flying daily. And those magnificent bastards I flew with there knew how to get a heavy jet in and out of some odd places with minimal support from back home. The depth of knowledge on international flying there was amazing. I wouldn't trade that experience for anything. Overall, I am happy to be here.... and it was definitely the right career move.