Regional "career" is risky, it often ends with your regional liquidating right about when you're at your peak career earnings and too old to practically start over somewhere else. I can think of four liquidated regionals in recent memory off the top of my head, about to be joined by number five.

So I would shoot for the majors (if you go the airline track). If you get stuck at the regionals, it will *probably* work out OK, but do yourself a favor and don't choose that now. If you get into a good position, good QOL, extra income from training dept, etc then you might have a reason to choose to sit tight. Also I'd say the large regionals are far more secure over the course of a career... if you're thinking of staying I'd keep that in mind