Iran's proxy, Hezbollah is linked to the deaths of over 300 Americans in attacks in Lebanon during the 1980s. These attacks included the 1983 bombing of the U.S. Marine barracks in Beirut, which killed 241 American service members. Additionally, Hezbollah was implicated in the 1983 bombing of the U.S. embassy and the 1984 bombing of the U.S. embassy annex, both in Beirut. The group has also been linked to the 1996 Khobar Towers bombing in Saudi Arabia, which killed 19 U.S. Air Force personnel.

Iran's proxy, Hamas murdered 43 American citizens and took at least 10 American citizens hostage.

Iran's proxy, the Houthi's have been attacking commercial vessels and US forces.