It's possible but most people wouldn't recommend it. You're introducing an extra layer of failure that can happen every time you try to go to work. What area are you trying to commute from? Based on that, you can probably do the research and see how many flights per day to your intermediate point, and then how many from there to the UA hub you'd want to work at. Now take into account whether they are RJs or mainline, and whether it's on UA or OAL.

Unless there is some kind of non-negotiable, unavoidable reason you have to stay somewhere, I would avoid a 2-hop commute like the plague. I know quite a few people who do a 1-hop commute and it's not uncommon for them to have to jump in their car and make the drive. People get stuck in their hotel or crash pad because they couldn't make it home. And that's with 1 hop, not two.