The CRJ-450 isn't about a smaller jet or getting around SCOPE, it's already allowed by SCOPE, it's about adding premium seats and getting rid of single-class airplanes. It's about advertising premium seats on every flight.
It's cost per seat-mile are higher, but the revenue per seat-mile will be even higher than that. Passengers booking premium seats won't have legs in small, RJ-sized, economy seats. They'll have premium seats for their entire trip. That will keep them from going to competitors to avoid the economy seat.