Guys, we're entering a downturn in our industry of epic proportions, we haven't begun to see the worst of it, in fact, it hasn't even begun yet. Several waves of furloughs at many carriers will take place, flooding an already saturated market w/ more qualified pilots looking for work that won't exist.
So get in while you can, if flying 121 pax is what you would like to do. There is no time to be picky, it will likely be several years before any appreciable hiring resumes as fuel prices and severe downturn in the economy will stifle commercial travel in our country through, optimistically, 2010. Get in while you can, or be prepared to wait it out into the next decade (Assuming your goal is to stay here in the U.S.).
It's your choice.