Even if we all had the crystal ball it would still be a tough decision. About 10 years ago Delta and United were the highest paying pilot jobs and UPS and Fed Ex were quite a bit lower. 2 years ago Express Jet was one of the best regionals to work for and now they are about to furlough 1/4 to 1/3 of their pilots. Even Horizon which is considered a better company and wholly owned is also getting ready to furlough. Mesa, which is commonly referred as the worst is hiring and all of their pilots are still there. There is no guarentee and the 'best' company to work for changes constantly.

I think you should just wait it out to see what happens where you are at. Unless you know for sure you will be gone, there is always a chance that you will still have a job. You were smart to try to stay at your first company and try to upgrade faster, that is the goal, PIC time and on to the majors to start the gamble all over again.