What I love about pilots, they are by far the most opinionated group you ever want to meet. You got to love it. Nevertheless, it simply depends on personal preference. I have flown both 121 and 135 (AirNet) and I had a fantastic time doing both, but for pilot growth and experience, single pilot IFR at night is the most demanding. Some people don't like demanding. The older I get, I don't like demanding either.

Now at this stage, I wouldn't even give AirNet a second glance. Nothing against the AirNet pilots, I'm just a morning person.
Usually the way it works, once you build the time and experience, then you go on to Southwest, Jet Blue, Net Jets, etc, etc (that is what other pilots from AirNet did).
Like any company, what puts a dark shadow on AirNet is the management and dispatch. They are pretty f_cked up. What I don't like about the Regionals is the pay, it is awful. I myself finally switched over to fly for the Federal Government, something about job security and retirement is very appealing.
With the fuel prices and the economy as a huge factor, I wish everyone the very best in their airline careers.