lets see..... v1 cut in the E170.... almost... a non event....

engine failure at v1... especially #1 or #4 in a Hercules... now that is a bit more demanding. Or two out on the same side in a Hercules... NOW that will get your freaking attention... ( i suspect two out on one side of say the DC-8, B707, or 747 could be a challenge as well )

and if you REALLY want to kick it up a notch.... in the sim have an outboard ( 1 or 4 ) go to max reverse during take off.... hum.... enlightening....