The time away from home is a real deal breaker. Just think of all the great moments with your family that you will miss. Being junior on the seniority list with no vacation for the first few years will be tough. You need to have a strong spouse who has lots of extra time and money. ADD to the list - Very forgiving and understanding.
If you work and live in the same place life will be much better. Think of all the extra time you are away from commuting. Even if you only spend 5hrs on either side of the trip getting home it adds up at four trips a month. 40hrs(1.6 days) a month x 12= 19.2 days. That's being conservative for a normal commute. I would say that you would spend an extra month away from home commuting. Granted some times you run over to the plane after your last leg and get right on. But other times you miss the last flight out, get bumped on the first three flights in the morning just as snow storm hits. All this while your wife is calling telling you that a kid just went to the hospital and the toilet is overflowing. That is not worth the 20k you will make that year.
Is your life really worth that little? Sorry bad rant here but I hate hearing how people think that this commuting business is so easy. Without a family and responsibilities it could be a lot more fun.