22" ABS here, mostly CAL, SWA, and NWA. While it will fit in the RJ and CRJ overhead bins, gate agents won't let it as it might set a bad example for the other pax. Whatever.

I find if you use the 3 oz bottle of hair gel, the ipod NANO, and put the raybans in the kit bag, your 22" is just fine for a week or longer trip.