"Hi folks, welcome aboard this flight to ____ , I'm Erik your FO with your Captain _____ , just a few quick safety items to cover before we leave. There's ____ exits in the aircraft, the door you came through, emergency exit in row 2 and the crew door over the captain's left shoulder. There's a fire extinguisher underneath my seat and life vests underneath your seats (insert humor if we're flying nowhere near water and I'm in the mood i.e if we find any water, we'll know I've gone too far/gotten lost/have bigger problems). Please keep your seatbelt buckled (if I know it's going to be a bumpy flight I'll let them know now) until we come to a complete stop and keep your cell phones off until you get inside the terminal. There's no smoking on the flight. There's an informational briefing card in the seatback pocket in front of you if you have any questions. What you can do today is sit back, relax and enjoy the flight to _____. Thanks for flying with us today."
I'll sometimes turn around during the flight if we're not too busy up front and ask the passengers how the temperature is, let them know how much longer we've got, if we're flying over something cool like the Olympic facilities in Lake Placid, NY for example.
Then when we arrive, I'll turn around and welcome the passengers to wherever we just landed, let them know that an agent will get the door for them in a moment and then thank them again for flying on us.
Hope this helps.