With most of the Higher Tier Regionals (you choose your own for that designation) not hiring....most contracts for regionals don't have soft money and few min days off....it all depends on where you live now, where you want to live and where the carrier flies! IE are you going to be delayed in LGA for 5 hours and screw up dinner with the wife?
No one can tell you what makes a #1,2,3...etc airline for YOU! You can get this sort of information by digging here, and the carrier's own websites, how are they doing financially is important too. Will they be here for 5 years or so until you move on, or make a career out of a regional.
These are the sort of things you search out on the interwebnet and sit down with HomeRaiser6 to tell you where you will go to apply when the well starts collecting water again for the pools that have dried up. Then is when you put your line in the water to try and catch that mythical Higher Tier Regional!