Gettig back into the industry wouldn't be too difficult, but to get a major to hire you with zero recent flight experience would, IMO, be very difficult. It would depend heavily on who you know and how many recommendations you get. My advice to you is if you have flying job now, hold on to it. There are too many pilots out there on the street that would love to be in your shoes. Plus, it will be much easier to get in with a major when they do start hiring again if you dont have any big gaps in your recent flying career.