I work at Express and generally I would say you would need to be around 1,000 with 150 multi. I don't fly with to many new hires though so not real sure what people are getting hired with. We have an agreement with All ATP and they will interview with 500 total time. I think the minimums are still 600 and 100, but like Ottopilot said it changes often.

They hire every one from CFIs to 121 to 135 and corporate. It never hurts to apply. Internal reccomendations help out a lot but aren't required.