In the regionals seniority isn't everything
If you plan on going to a regional and building seniority until you can hold a line as captain, you are going the longest possible way to a major that you can. I guess if you plan on staying at a regional for life then seniority is everyting. There are many other ways that you can get captain time without having to sit FO for 4-5 years at a regional. Small freight operators that have twin turbine airplanes are one option, also small airlines with quick upgrade times are another. Either of those ways will get you captain time faster than going straight to a regional.