Fast answer that is factual, it really points to training. Inexperience is a normal part of the process. It is the training involved and how the 'inexperienced' are trained. The focal point will look at training.
Example: I am a heavy driver Captain very experienced in domestic 121 operations. I now go to a new heavy airplane flying worldwide 121 international operations, Atlantic/Pacific/South America.
I am now an inexperienced pilot despite previous domestic experience.
Now the focal point goes to training, if properly trained and brought online with crews trained and experienced in these operations, chances are that I will become 'experienced' in a safe manner.
The challenge is that many operators want to do it on the cheap. Thus, inexperience can get people into trouble, but really it was often poor training by the company.
Fire away..