I would put Large Twin TurboProp (Q200,Q300,Q400, ATR72...)as number one. Especially if it is flown as cargo. But this is an argument that has to many variables. Actual IMC in the Pac Northwest and Alaska rates higher than Actual IMC in Nebraska. Actual Instrument Approachs in a Jet at the speeds that a Jet flies at compared to what a single piston would shoot the same approach at make a significant difference.
But I have to agree with USMC. Some of my sim flights have been the most intense flight situations I have ever been in. But again the difference between being a student in a Frasca sim and at flight safety in a 10 million dollar full motion sim is night and day.