It depends on the type of job he's going for. Typically, airlines who are hiring for a pilot position won't care much about where the degree is from, as long as he has one (if that is their requirement.) If he's applying for a "desk job," say an analyst of some sort, then where he obtained his degree may be factored in the equation with more weight.

There are several posts here about how to go forward with an online degree and I wholeheartedly agree that it MUST be from an accredited college. If he ever wants to use that degree in another fashion, as a fall back, then the more recognizable the institution name the better.

[one caveat] If the institution he chooses has a disreputable name (commonly known as a degree factory) the education may be "discounted."