Chris:
You have it right in your first post. Assuming you have a choice, it is wiser to go to the place that is the quickest path to 1000 hours PIC.
I have friends furloughed from USAirways after 14 years who are not qualified to apply to SWA, JBLU, etc because they don't have 1000 hours PIC. Well, that was the case when they were furloughed, most that needed that time got it by taking a J4J position. Anyway, the point is that sitting in the right seat of a CRJ/ERJ for years on end is a waste of time if your goal is to get on with a major. Don't listen to the defeatist attitude that Regionals are career stopping points nowadays. Some can be okay, but if your goal is to go beyond that it is better to get that 1000 hours PIC as quick as possible.
The other important thing to do is network, network, network.
Typhoonpilot