What hasn't been mentioned here is how competitive a UPT slot from most guard/reserve units are (Faribanks, AK might be one exception, but in this economy, who knows). Getting hired as an already-rated guy is one thing, but getting a UPT slot from the ANG/USAFR is another entirely. Many units give strong preference to enlisted guys in their own units, and then to prior enlisted and officer Active Duty guys. The way around this is to know someone in the unit or to meet the guys in your desired unit, fit in, and buy a LOT of beer.

If the OP does not have a contact in the unit of his choice, and does not care to enlist in said unit first, AD seems like a very palatable option. After all, how much less than 10 years will his time in the ANG amount to, if he has to enlist, attend basic training and tech school, excel in his career field, get noticed, get picked up for UPT, etc. etc. etc...

Of course, on AD you might get stuck in a UAV at some point. But you've got a lot of hours and have already been hired at a 121 carrier. This will help you significantly when you want to apply at Airline X and go back to the 121 world.

But, most importantly, like FatBoy said...Officer first, pilot second. You will be serving, sacrificing, and LEADING, guaranteed. Make sure you and your spouse/family are aware of the possible scenarios...