This can go two ways (pun intended). Fly something with some serious horsepower on each wing and lose one. Also, fly something with less than serious horsepower on each wing (ala Twin Comanche). Either way, you will have your hands full. It's just that the larger plane with more power and weight has more momentum to swing one way and really make your leg tired until you get the rudder trim in. The Twin Comanche (got my multi in one) is great on two. Lose one on a warm day, the other one will just take you to the scene of the accident (hopefully joking here). You HAVE to be on your toes.

Now, you lose an engine in a single, no question what's going to happen. Been there, done that twenty years ago. I'm done.