My sim partner from training had a strange situation that he now thinks will certainly keep him in the regional ranks forever. He went in for the oral, busted for various reasons, came back the next day, passed the oral, hopped in the sim, had an awful day, then failed the sim. Even though this was all for the same event, apparently training records show this as 2 seperate failed events since they were on different days with different instructors. Although this happened several years ago and he hasn't had any problems since, makes you really want to go in prepared as it seems with the new legislation, a situation like this would probably make any major throw out your application without thinking twice. As for one remote failure though, explain it and learn from it, and I'm sure you'll be fine.