The answer is YES. Maybe a better question would have been, "will the majors fly a 100 seat aircraft?" The CRJ1000, EMB190,C-Series, ect. are being manufactured not to be flown by Delta, American or Continental, but by the likes of regionals. Infact, Republic ordered 80 C-Series and just ordered another 20 EMB190s. There's absolutely nothing that can be done to stop this. And if anybody says "scope" can stop this, you're either an industry newbie or really blind to what's been happening in the US aviation market.