FedEx operates an MD-11, I believe, 6 of the 7 days a week. By this I mean they leave EWR at around 3 AM and arrive in ANC at about 7 AM. There's one night that they don't operate, so I was taking the EWR MD-11 to ORD, then after about an hour layover, took the MD-11 up. In the year I was based there I never found it difficult to commute. Just Looooooong. The good news was that you could sleep in the back on the way up. I don't believe I ever had more than one or two other jumpseaters on board, so the corporate futon was usually available. I never jumped up to operate the same day, as I thought that was just dumb. So I'd ge to the B&B for the day, see friends for dinner, perhaps stop by the F Street to say Hi, and operate out to Asia the next day around 10 AM.

Getting back from ANC was the same in reverse, except that if you were late arriving from your trip, your ride might have already left. In a year that happened to me once. Forced me to do the B&B thing until the early AM and then took an MD-11 to Mecca-Red-Necka, and then the Airbus home. Otherwise, if all is working as advertised, you'd get back to ANC around noon or 1 PM, with the EWR jet scheduled to leave at around 2:30 PM. Time to change clothes, check the internet, call the wife to remind her to kick out the 4th Army Reserve unit and then board the flight back to EWR. All in all, it worked fine. It's just a very loooooooong commute. Good luck.