I got hired with a guy at Skywest with a guy that had left Atlas by his own choice. He was right seat in the 747 making decent money (by regional standards, not great for the 747) and left to come work at Skywest for $19/hour. He said he couldn't take the schedule anymore. He talked about getting extended and geting his long (17 day trips) lined up back to back , which kept him away for more than a month at a time.
I thought it was pretty telling for an international widebody pilot to be willing to start over at a regional. He was single, so it wasn't like he was trying to keep a family on the tracks either.