This discussion about a year ago sums up the problems with single-pilot airliners that rely on an operator on the ground to recover the aircraft in the event of single pilot incapacitation (essentially an unmanned vehicle):

http://www.airlinepilotforums.com/te...airliners.html

You'll never get the level of safety expected from today's airliners without two pilots up front.

And start unmanned transport small, with buses, cars, trains, and other ground-based transportation before graduating to higher-level transport.