The AIR Inc. ones are OK. If you have 1/2 a brain the "seminar" is a waste of time (except for the industry news/health check), but it is included in the price, and includes food so you might as well go. No bad info, I just found the interview prep monotonous since I had done a bunch already. The Job fair in the afternoon is money - bring resumes tailored for each company you might be interested in, a couple generic in case someone unexpected shows (like Skybus at the DC fair) and make your way around.
More importantly, a great way to ask good questions in a neutral forum and it's a good opportunity to start/work your network with the other attendees, not to mention comparing job notes.
It means a lot to some companies if you put the effort in to go - CitationShares, NetJets, and AirTran among others. This is general true of all job fairs, flying or not. Effort counts. And you never know who you'll meet so be professional all day long; in the case of my Comair interview, the Capt I interviewed with had talked with me at the fair!
Summary: for Air Inc, worth the money to do once.