Interestingly enough...
I'm working through my backlog of Aviation Week, and March 15 issue has an article about an NSTB study which looked at TAA safety. This is the first major study of it's kind since TAA's are fairly new.
For light piston airplanes, the TAA's have over DOUBLE the fatal accident rate compared to steam gauges. (1.03 vs 0.45 per 100,000 hours).
I suspect some of that has to do with mission and demographics...on average TAA's are flown by older (wealthier) folks who may come to aviation later in life (old dogs, new tricks and all that). More capable airplanes flown by older pilots tend to fly longer missions with more opportunities to encounter weather and more get-there-itis.
The article focuses on training and the challenge of managing TAA systems. It's easy for two professional pilots to manage TAA but I'm not sold on it being easier on a single private pilot.