The original question was how to respond to the question, if asked. Of course, assumptions like, "the VOR has to be in a lower MSA, so fly over there" are a great way to paint yourself in a corner during the interview.
Don't make it up. If there's not a prescribed procedure in regs, SOP, etc, then use ALL the tools at your disposal. Ask the other crew member. Ask ATC. If no obvious answer is immediately apparent, I'd say CLIMB and get to the missed approach (assuming you are below the MA altitude). Obviously, any missed will require specifics from the approach to determine how to do that. Maybe there is a NOTATION on the chart just for the possibility of loss on a navaid signal.
If asked the question, methodically think it through if you don't know the answer. Guessing, assuming... bad plan.