Are you current? If not, that will probably be a show stopper in this hiring market. Can you afford to get current? Are you a CFI? If so that's probably your best short-term bet.
In addition to basic FAR currency, you will generally need 50-200 hours in the last 12 months, read the fine print on each airline's website for specifics.
Once all that is resolved, potential employers will wonder about your history...
Regionals will suspect you are overqualified and won't last. You will need to come up with a good song and dance to convince them that you will be OK with $20K, sitting reserve, and working for captains who are about half your age. I have no idea what you should tell them.
Majors and 135/91 will wonder why the long break. Maybe you could say that you have wanted to return to aviation for years, but the job loss was actually a "blessing in disguise" which enabled you to pursue flying again.
You need to get current, come up with a good story, and then start trying to get an inside recommendation from someone...that's still how you get most aviation jobs.