I landed a Seneca in a tropical storm about 12 years ago. Winds were 46G70something, about 45 degrees off. I was carrying a heart for transplant, to a reciepent that needed it right now. God smiled for the 60 seconds it took to land off the RNAV appch (which I shot with a handheld GPS), as I was granted a very short lull in the wind and made for a "relatively" uneventful landing.