Depends on how much your wife can handle. I was single for part of my AMF life and it was easier on the budget/lifestyle. However the ROI with AMF is a good one. Majority of people move on to charter/air ambulance/aerial firefighting etc. Go the Regional route, its generally the game plan to go onto majors or similar. Can't speak for all 135 ops, but its generally a challenge to go from that to flying air ambulance and probably some charters. Single pilot IFR skills are a thing to highlight on a resume.