I think the important thing is that the new F/O realizes that he/she has a LOT to learn. Whether you have 50,000 hours as a CFI or 220 hours total time fresh from a 141 program. A lot of guys get their 1,000 hours or 3,000 hours and think they know everything. That's a bigger problem than the 250 hour guy because now you have a mind set to do it a certain way.
The argument has been made for CFI experience for knowing the VFR traffic... at 250 hours you have a pretty good idea of what traffic is going to do.
It's more important what kind of flying you did IMO and how comprehensive your training was. A pilot from a major 141 program will probobly know more at 250 hours than a part 61 guy just because of the large amount of classroom time involved. I had classes for my degree that were directly related to things that are good to know for aviation.
If you can get hired and make it through training with less time, then good for you. I'm all for it.