If you fly cargo, you fly fatigued, there is no way you leave the hotel at 2 am, fly 4 legs and return at 9 pm and you were not fu@# up at some point of that trip.

And which cargo outfit has the schedule you speak of?

Geeesh, that blows - totally true flying THAT cargo trip. I prefer the one long haul leg, maybe 2. Decent layovers sometimes odd hours will bring brain drain, but for the most part 18/24/30 or more hrs off is casual. Totally agree doing that crap flying above guarantees zombie outcomes, I see day I see night or both but not all cargo flying is equal.

I'd say your body gets used to everything. I woke up at midnight last night, for a 3am departure, done at the hotel 4h later. Are those weird hours? You bet, but once you understand it is part of the game, it sure has big benefits.
I think we were 3 or 4 airplanes on the west coast at that time lol, plus a couple of owls. And layovers are longer

One that I know very well, but it is not a schedule, those are special “very much needed revenue” charters and sometimes it’s even worse than that (last leg being “part 91” of course)

Yeah that’s tough stuff, but not the Cargo norm although hub turns are not ideal as well.

Being tired and being fatigued are two different things.