Originally Posted by rickair7777
(Post 3209137)
Possible link to rare blood clots in AZ recipients, suspected to be associated with birth control pills (most patients are young women). The type of blood clotting is already known to be associated with pregnancy and contraceptives.
Also some suspicion that publicity around these events may have lead to higher reporting, which would skew the observed statistical prevalence. It doesn't make much sense, given the suspected auto-immune mechanism, that only AZ but not other other vaccines would produce this side-effect. So there may be heightened sensitivity with the public and healthcare providers to an issue that has other causes. https://www.reuters.com/article/us-h...-idUSKBN2BC01M Or it may be entirely real, and STILL not a sufficient reason to not get vaccinated. Every single woman on birth control pills is increasing her risk of having strokes, but 12.6% of women of child bearing years still take the Pill. |
Originally Posted by Excargodog
(Post 3209151)
Or it may be entirely real, and STILL not a sufficient reason to not get vaccinated. Every single woman on birth control pills is increasing her risk of having strokes, but 12.6% of women of child bearing years still take the Pill.
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Many people, and most of the hysterical media do not have a clear grasp on cost / benefit analysis. What is the trade off?
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Originally Posted by TransWorld
(Post 3209636)
Many people, and most of the hysterical media do not have a clear grasp on cost / benefit analysis. What is the trade off?
Expecting immunizations to have no risk is unrealistic. |
Scientists and officials still disagree about statistical prevalence of blood clots in AZ recipients.
Some in Europe believe it is caused by the vaccine, but should be easy to treat when patients recognize the symptoms. https://www.npr.org/sections/coronav...lood-clot-link |
AZ completes US trials: 79% efficacy, and no increased risk of blood clots observed, and proven efficacy in older adults (foriegn trials did not address that last issue adequately for the US regulators).
Presumably that efficacy includes the various mutations, to some degree or another. AZ has potential for use in the developing world because it doesn't require the special cold-chain handling (just normal fridge temps) https://www.reuters.com/article/us-h...-idUSKBN2BE0IB |
AZ criticized for data presentation in yesterday's press release. Considering their previous confusion with stage-3 trail dosages, it might be time for AZ to slow down a bit...
https://www.reuters.com/article/us-h...-idUSKBN2BF1RE https://www.reuters.com/article/us-h...-idUSKBN2BF1HE |
Sinovac says it's vaccine is safe for kids as young as three. This bodes well for other vaccines as well, but the west probably won't be as quick on the draw with child trials as the PRC.
https://www.foxnews.com/health/sinov...-as-young-as-3 |
Rick,
A comparison as to long term risk was made up thread about Thalidomide, any thoughts ? |
Originally Posted by galaxy flyer
(Post 3210537)
Rick,
A comparison as to long term risk was made up thread about Thalidomide, any thoughts ? Vaccines don't typically cross the placental barrier, and the mRNA vaccines specifically are believed and assumed not to cross it. The placenta tends to keep out larger, complex molecular structures (HIV for example can't get to a baby that way, mother=>child infections occur via blood during birth trauma). Viruses typically have a molecular weight in the range 10^4 - 10^5 Da. Alcohol (which definitely crosses the barrier) has a mol weight of 46 Da, mRNA is about 1000 Da. IIRC 600 Da is about the threshold for crossing the barrier, but there are also some chemical factors in addition to size. Thalidomide is 258 Da. I'm confident that the vaccine delivery package is larger than the mRNA it contains, so that's probably not crossing either. Even if mRNA did cross, the worst that would happen would probably be an immune response in the baby. Vaccination of the mother actually can provide some immunity for a baby... the vaccine doesn't get to the baby but the mother's immune response does. Some vaccines are given to expectant mothers specifically for that reason. Formal trials with mRNA vaccines have not been conducted on pregnant women, but that is planned soon. There is some informal data... a couple thousand women in the trails actually did get pregnant inadvertently, and there were no observed issues that could be related to the vaccines, or any statistical anomalies. |
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