Excargodog

From the CDC website: https://www.cdc.gov/coronavirus/2019...iew/index.html

With an ‘n’ as big as this group you’d expect even a 1.3 relative risk to have a p value of less than 0.05...

rickair7777

Not adjusted for comorbidities, or socio-economic conditions. So no real surprise if you consider those factors.

Hard to draw any conclusions about innate ethnic biological susceptibility without adjusting for health, living conditions, cultural behavior patterns, etc.

Excargodog

But that’s why you DO the studies, to start teasing out the variables to discover the true nature of the disease. We need a huge multivariate analysis of variance table to get at that data. And I’ll concede that - except for known issues like sickle trait and sickle cell anemia - it may not be a race based susceptibility at all. But it does serve as a warning to those people who think that if we can institute the same restrictions as Singapore, Taiwan, BFE, or wherever, our stats will magically align with theirs..l

Ronaldo

From day one in dealing with this “people have been saying” ACE2 gene expression is likely linked to negative outcomes like it was in SARS and other Corona viruses. Whether ACE2 expression increases with age and is different between races and genders is an important question.

Now that racial disparity is available it would be interesting to look at several avenues to understand COVID outcomes.

I’d say practical economic factors like health insurance, availability of sick leave, ability to take a pay cut or miss work, and distrust of medical treatment are probably heavily involved in the disparity. I’d also posit that lower income neighborhoods are frequently located near industrial centers, where air pollution could influence ACE2 expression.

Here’s one review on it. I’ve seen some articles on the racial disparity in the NYT, Atlantic and or Ars Technica.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499935/

Excargodog

It could also be just locale. Big cities with high population densities have historically been the worst place to be in a pandemic. Just too dang many chances to get it. Nonetheless, a four-fold difference in hospitalization rates with an ‘n’ this big is a HUGE difference.

firefighterplt

Purely anecdotal, but my sister was an RN in a C19 ICU and she said her patients were overwhelmingly minorities with obesity and/or diabetes.

I’d love to see the stats controlled for those comorbidities as well.