I used Medifast and went from 260 to 210 in about 4 months. I kept it off for 1.5 years until i got distracted by a home move/purchase and some lousy weather that kept me off my bike for half a year. I'm now at 245 and not happy about it.
Medifast is a food replacement (you buy it from them) and is basically a vitamin enriched protein based food. The soy bars are easy to travel with so it works for pilots It is also a multi level marketing scheme with your "coach" making some money off all your purchases. It works however because you will enter in to ketosis and burn fat. It's basically the same as Atkins but more nutritionally balanced.
If you want to get the name of my coach and enrich him, PM me. I have never been interested in sales. Look um up and see what you think.