The regional with good qol today may be garbage 5 years from now. Pick a place close to your home if you're absolutely dead set on this awful career and settle in. Even then that base may close (Eagle has closed both San Juan and LAX since I've been here) so be prepared to commute eventually. You're going to spend an extended period of your life at the place you choose so be sure you can handle it. A legacy or major job is not "just around the corner" unless you did an internship or happen to be some sort of minority.

In closing also be prepared for a multitude of scare tactics and uncertainty. It's been said in this thread already but it looks like we're starting a period of upheaval in terms of pilots rejecting concessionary contracts. Management teams are going to do everything they can to reverse this trend, be prepared for pain and don't give in, we can win this eventually. Also, please don't go to PSA.