My resume is pretty competative at several majors. I've been reading through a ton of "aviation interviews.com" postings, and the real key is not the resume, but having someone walk in your paperwork. I worry that my 3-years away from flying will be an issue with the majors (and the regionals). I definitely intend to try for a major, but I'm okay with the regionals too - just want to get my foot in the door and air under my arse again.