Better in all areas.

QOL is subjective, but the vast majority of fracs are on a 7 and 7 schedule. You work seven on, then you know that you'll have seven off. The seven on gets long, but the seven off is really nice.

If you want to get extra money, you can work overtime. This is on a flat daily rate at my company and it all goes above guarantee. Per diem is about twice what I was making in the regionals.

Our minimum rest is ten hours, that is much better than the regionals. One downside is that there is some airport standby. This can vary with company, location, aircraft, day, and phase of the moon (j/k). Duty days are 14 hour maximum and crew meals are available if needed.

The flying is great. I typically go international about once a tour. This can include Mexico, the Caribbean, and Canada. Every tour I go to at least one new airport. We go into big and small airports. Anything longer than 3500 is fair game. I have flown as little as 15 hours in a tour or as many as 40. 20-25 is about average for me.

It isn't for everybody, but I like it a lot better than the regionals. I got a pay raise, more days off, and a quicker expected upgrade the first day I started here.

The main downsides are the long periods away from home and the increased responsibilities of the flight crew. Aside from the obvious, like cleaning, lav handling, baggage handling, passenger briefing and relations, we also file our own flight plans and get much less dispatch support than you are used to. Hidden "gotcha's" are probably multiplied at least tenfold over airline flying, so make sure your AOPA legal is paid up.